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COPD
A practice question in the style of the MCCQE MCQ exam. Choose your answer to see the explanation.
A 74-year-old man with COPD (FEV1 38% predicted, four exacerbations last year, on home oxygen) has purulent sputum and increased breathlessness. Which antibiotic is most appropriate?
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The answer is B: Amoxicillin-clavulanate.
FEV1 below 50%, frequent exacerbations and home oxygen make this a complicated exacerbation, which calls for amoxicillin-clavulanate or a respiratory fluoroquinolone to cover resistant organisms. Amoxicillin, doxycycline and trimethoprim-sulfamethoxazole are for simple exacerbations. Nitrofurantoin is a urinary antibiotic.
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