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Adrenal and pituitary disorders

A practice question in the style of the MCCQE MCQ exam. Choose your answer to see the explanation.

A 50-year-old woman has weight gain over the trunk, a round face, purple abdominal striae, easy bruising and proximal weakness. She takes no steroid medications. What is the most appropriate first test?

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The answer is C: 1 mg dexamethasone suppression test.

Suspected Cushing syndrome is screened with an overnight 1 mg dexamethasone suppression test, a 24-hour urine free cortisol or a late-night salivary cortisol. Imaging comes only after biochemical confirmation, because incidental pituitary and adrenal lesions are common.

This question comes from Week 4 of MCC Vault: Endocrine, diabetes and metabolic. That week has 124 more exam-style questions like it, 5 short lessons and 155 flashcards. The course starts free with Week 1 and reaches this topic in week 4, as part of a five-month plan with full mock exams along the way.

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