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Adrenal and pituitary disorders
A practice question in the style of the MCCQE MCQ exam. Choose your answer to see the explanation.
A 50-year-old woman has weight gain over the trunk, a round face, purple abdominal striae, easy bruising and proximal weakness. She takes no steroid medications. What is the most appropriate first test?
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The answer is C: 1 mg dexamethasone suppression test.
Suspected Cushing syndrome is screened with an overnight 1 mg dexamethasone suppression test, a 24-hour urine free cortisol or a late-night salivary cortisol. Imaging comes only after biochemical confirmation, because incidental pituitary and adrenal lesions are common.
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